Mutations in arrestin alpha‐helix I affect receptor binding
نویسندگان
چکیده
منابع مشابه
Mutations to the kainate receptor subunit GluR6 binding pocket that selectively affect domoate binding.
Kainate receptor responses to domoate are characterized by large steady-state currents and slow deactivation kinetics. To improve our understanding of these responses, we mutated residues at the mouth of the agonist binding pocket of GluR6 using whole-cell electrophysiology to characterize the effects of the mutants. We identified two residues where mutations had significant ligand-specific eff...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.22.1_supplement.1046.6